Serum Potassium, Mortality, and Kidney Outcomes in the Atherosclerosis Risk in Communities Study.

ABSTRACT:

Objectives

To investigate the association between serum potassium, mortality, and kidney outcomes in the general population and whether potassium-altering medications modify these associations.

Patients and methods

We studied 15,539 adults in the Atherosclerosis Risk in Communities Study. Cox proportional hazard regression was used to investigate the association of serum potassium at baseline (1987-1989), evaluated categorically (hypokalemia, <3.5 mmol/L; normokalemia, ≥3.5 and <5.5 mmol/L; hyperkalemia, ≥5.5 mmol/L) and continuously using linear spline terms (knots at 3.5 and 5.5 mmol/L), with mortality, sudden cardiac death, incident chronic kidney disease, and end-stage renal disease. The end date of follow-up for all outcomes was December 31, 2012. We also evaluated whet

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5531173 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature