B-1a Cells Protect Mice from Sepsis: Critical Role of CREB.

ABSTRACT: Bacterial sepsis is a serious life-threatening condition caused by an excessive immune response to infection. B-1 cells differ from conventional B-2 cells by their distinct phenotype and function. A subset of B-1 cells expressing CD5, known as B-1a cells, exhibits innate immune activity. Here we report that B-1a cells play a beneficial role in sepsis by mitigating exaggerated inflammation through a novel mechanism. Using a mouse model of bacterial sepsis, we found that the numbers of B-1a cells in various anatomical locations were significantly decreased. Adoptive transfer of B-1a cells into septic mice significantly attenuated systemic inflammation and improved survival, whereas B-1a cell-deficient CD19^-/- mice were more susceptible to infectious inflammation and mortality. We

SUBMITTER: Aziz M 

PROVIDER: S-EPMC5531203 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature