Effect of vitamin D₃ on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial.

ABSTRACT:

Introduction

Vitamin D₃ supplementation has been reported to prevent lung infections and increase the gene expression of antimicrobial peptides such as cathelicidin. We investigated the effect of vitamin D₃ supplementation on the antimicrobial activity of airway surface liquid (ASL) in human subjects. Since smoking can increase the risk of respiratory infections, we also investigated the effect of smoking in the cathelicidin response to vitamin D₃ in human airway epithelia in vitro.

Methods

This study is a subanalysis of single-centre community-based randomised placebo-controlled double-blind trial. Participants were randomised to receive 1000 international units per day of oral vitamin D₃ or identical placebo for 90 days. Blood an

SUBMITTER: Vargas Buonfiglio LG 

PROVIDER: S-EPMC5531307 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature