Role of STIM1 (Stromal Interaction Molecule 1) in Hypertrophy-Related Contractile Dysfunction.

ABSTRACT:

Rationale

Pathological increases in cardiac afterload result in myocyte hypertrophy with changes in myocyte electrical and mechanical phenotype. Remodeling of contractile and signaling Ca²⁺ occurs in pathological hypertrophy and is central to myocyte remodeling. STIM1 (stromal interaction molecule 1) regulates Ca²⁺ signaling in many cell types by sensing low endoplasmic reticular Ca²⁺ levels and then coupling to plasma membrane Orai channels to induce a Ca²⁺ influx pathway. Previous reports suggest that STIM1 may play a role in cardiac hypertrophy, but its role in electrical and mechanical phenotypic alterations is not well understood.

Objective

To define the contributions of STIM1-mediated Ca²⁺ influx on electrical and

SUBMITTER: Troupes CD 

PROVIDER: S-EPMC5531450 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature