Applying time-frequency analysis to assess cerebral autoregulation during hypercapnia.

ABSTRACT:

Objective

Classic methods for assessing cerebral autoregulation involve a transfer function analysis performed using the Fourier transform to quantify relationship between fluctuations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV). This approach usually assumes the signals and the system to be stationary. Such an presumption is restrictive and may lead to unreliable results. The aim of this study is to present an alternative method that accounts for intrinsic non-stationarity of cerebral autoregulation and the signals used for its assessment.

Methods

Continuous recording of CBFV, ABP, ECG, and end-tidal CO2 were performed in 50 young volunteers during normocapnia and hypercapnia. Hypercapnia served as a surrogate of the cerebral autoregulation impa

SUBMITTER: Placek MM 

PROVIDER: S-EPMC5531479 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature