BrEPS 2.0: Optimization of sequence pattern prediction for enzyme annotation.

ABSTRACT: The prediction of gene functions is crucial for a large number of different life science areas. Faster high throughput sequencing techniques generate more and larger datasets. The manual annotation by classical wet-lab experiments is not suitable for these large amounts of data. We showed earlier that the automatic sequence pattern-based BrEPS protocol, based on manually curated sequences, can be used for the prediction of enzymatic functions of genes. The growing sequence databases provide the opportunity for more reliable patterns, but are also a challenge for the implementation of automatic protocols. We reimplemented and optimized the BrEPS pattern generation to be applicable for larger datasets in an acceptable timescale. Primary improvement of the new BrEPS protocol is the enhanced d

SUBMITTER: Dudek CA 

PROVIDER: S-EPMC5531587 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature