Differential Requirements for Tcf1 Long Isoforms in CD8⁺ and CD4⁺ T Cell Responses to Acute Viral Infection.

ABSTRACT: In response to acute viral infection, activated naive T cells give rise to effector T cells that clear the pathogen and memory T cells that persist long-term and provide heightened protection. T cell factor 1 (Tcf1) is essential for several of these differentiation processes. Tcf1 is expressed in multiple isoforms, with all isoforms sharing the same HDAC and DNA-binding domains and the long isoforms containing a unique N-terminal β-catenin-interacting domain. In this study, we specifically ablated Tcf1 long isoforms in mice, while retaining expression of Tcf1 short isoforms. During CD8⁺ T cell responses, Tcf1 long isoforms were dispensable for generating cytotoxic CD8⁺ effector T cells and maintaining memory CD8⁺ T cell pool size, but they contributed to op

SUBMITTER: Gullicksrud JA 

PROVIDER: S-EPMC5531591 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature