Effects of dopamine on reinforcement learning and consolidation in Parkinson's disease.

ABSTRACT: Emerging evidence suggests that dopamine may modulate learning and memory with important implications for understanding the neurobiology of memory and future therapeutic targeting. An influential hypothesis posits that dopamine biases reinforcement learning. More recent data also suggest an influence during both consolidation and retrieval. Eighteen Parkinson's disease patients learned through feedback ON or OFF medication, with memory tested 24 hr later ON or OFF medication (4 conditions, within-subjects design with matched healthy control group). Patients OFF medication during learning decreased in memory accuracy over the following 24 hr. In contrast to previous studies, however, dopaminergic medication during learning and testing did not affect expression of positive or negative reinfo

SUBMITTER: Grogan JP 

PROVIDER: S-EPMC5531832 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature