Enhanced efficiency of cell death by lysosome-specific photodamage.

ABSTRACT: Mobilization of specific mechanisms of regulated cell death is a promising alternative to treat challenging illness such as neurodegenerative disease and cancer. The use of light to activate these mechanisms may provide a route for target-specific therapies. Two asymmetric porphyrins with opposite charges, the negatively charged TPPS_2a and the positively charged CisDiMPyP were compared in terms of their properties in membrane mimics and in cells. CisDiMPyP interacts to a larger extent with model membranes and with cells than TPPS_2a, due to a favorable electrostatic interaction. CisDiMPyP is also more effective than TPPS_2a in damaging membranes. Surprisingly, TPPS_2a is more efficient in causing photoinduced cell death. The lethal concentration on

SUBMITTER: Tsubone TM 

PROVIDER: S-EPMC5532215 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature