Establishment of patient derived xenografts as functional testing of lung cancer aggressiveness.

ABSTRACT: Despite many years of research efforts, lung cancer still remains the leading cause of cancer deaths worldwide. Objective of this study was to set up a platform of non-small cell lung cancer patient derived xenografts (PDXs) faithfully representing primary tumour characteristics and offering a unique tool for studying effectiveness of therapies at a preclinical level. We established 38 PDXs with a successful take rate of 39.2%. All models closely mirrored parental tumour characteristics although a selective pressure for solid patterns, vimentin expression and EMT was observed in several models. An increased grafting rate for tumours derived from patients with worse outcome (p = 0.006), higher stage (p = 0.038) and higher CD133⁺/CXCR4⁺/EpCAM^- stem cell conte

SUBMITTER: Moro M 

PROVIDER: S-EPMC5532258 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature