Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells.

ABSTRACT: Appropriate integration of GABAergic interneurons into nascent cortical circuits is critical for ensuring normal information processing within the brain. Network and cognitive deficits associated with neurological disorders, such as schizophrenia, that result from NMDA receptor-hypofunction have been mainly attributed to dysfunction of parvalbumin-expressing interneurons that paradoxically express low levels of synaptic NMDA receptors. Here, we reveal that throughout postnatal development, thalamic, and entorhinal cortical inputs onto hippocampal neurogliaform cells are characterized by a large NMDA receptor-mediated component. This NMDA receptor-signaling is prerequisite for developmental programs ultimately responsible for the appropriate long-range AMPAR-mediated recruitment of neurogli

SUBMITTER: Chittajallu R 

PROVIDER: S-EPMC5532276 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature