L _p -Adaptation: Simultaneous Design Centering and Robustness Estimation of Electronic and Biological Systems.

ABSTRACT: The design of systems or models that work robustly under uncertainty and environmental fluctuations is a key challenge in both engineering and science. This is formalized in the design-centering problem, which is defined as finding a design that fulfills given specifications and has a high probability of still doing so if the system parameters or the specifications fluctuate randomly. Design centering is often accompanied by the problem of quantifying the robustness of a system. Here we present a novel adaptive statistical method to simultaneously address both problems. Our method, L _p -Adaptation, is inspired by the evolution of robustness in biological systems and by randomized schemes for convex volume computation. It is able to address both problems in the general, non-conve

SUBMITTER: Asmus J 

PROVIDER: S-EPMC5532288 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature