Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia.

ABSTRACT: For decades, there have been observations demonstrating significant metabolic disturbances in people with schizophrenia including clinically relevant weight gain, hypertension, and disturbances in glucose and lipid homeostasis. Many of these findings pre-date the use of antipsychotic drugs (APDs) which on their own are also strongly associated with metabolic side effects. The combination of APD-induced metabolic changes and common adverse environmental factors associated with schizophrenia have made it difficult to determine the specific contributions of each to the overall metabolic picture. Data from drug-naïve patients, both from the pre-APD era and more recently, suggest that there may be an intrinsic metabolic risk associated with schizophrenia. Nevertheless, these findings remain con

SUBMITTER: Freyberg Z 

PROVIDER: S-EPMC5532378 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature