Metabolic Variability of a Multispecies Probiotic Preparation Impacts on the Anti-inflammatory Activity.

ABSTRACT: Background: In addition to strain taxonomy, the ability of probiotics to confer beneficial effects on the host rely on a number of additional factors including epigenetic modulation of bacterial genes leading to metabolic variability and might impact on probiotic functionality. Aims: To investigate metabolism and functionality of two different batches of a probiotic blend commercialized under the same name in Europe in models of intestinal inflammation. Methods: Boxes of VSL#3, a probiotic mixture used in the treatment of pouchitis, were obtained from pharmacies in UK subjected to metabolomic analysis and their functionality tested in mice rendered colitis by treatment with DSS or TNBS. Results: VSL#3-A (lot DM538), but not VSL#3-B (lot 507132), attenuated "clin

SUBMITTER: Biagioli M 

PROVIDER: S-EPMC5532379 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature