Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells.

ABSTRACT:

Background

Obesity and its comorbidities constitute a serious health burden worldwide. Leptin plays an important role in diet control; however, it has a stimulatory potential on cancer cell proliferation. The OB3 peptide, a synthetic peptide, was shown to be more active than leptin in regulating metabolism but with no mitogenic effects in cancer cells.

Methods

In this study, we investigated the proliferative effects, gene expressions and signaling pathways modulated by leptin and OB3 in human ovarian cancer cells. In addition, an animal study was performed.

Results

Leptin, but not OB3, induced the proliferation of ovarian cancer cells. Interestingly, OB3 blocked the leptin-induced proliferative effect when it was co-applied with leptin. Both leptin and OB3 activated t

SUBMITTER: Chin YT 

PROVIDER: S-EPMC5532776 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature