Metabolome alterations in severe critical illness and vitamin D status.

ABSTRACT:

Background

Metabolic homeostasis is substantially disrupted in critical illness. Given the pleiotropic effects of vitamin D, we hypothesized that metabolic profiles differ between critically ill patients relative to their vitamin D status.

Methods

We performed a metabolomics study on biorepository samples collected from a single academic medical center on 65 adults with systemic inflammatory response syndrome or sepsis treated in a 20-bed medical ICU between 2008 and 2010. To identify key metabolites and metabolic pathways related to vitamin D status in critical illness, we first generated metabolomic data using gas and liquid chromatography mass spectroscopy. We followed this by partial least squares-discriminant analysis to identify individual metabolites that were signifi

SUBMITTER: Lasky-Su J 

PROVIDER: S-EPMC5532782 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature