MiR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma.

ABSTRACT:

Background

miR-500a-3p has been demonstrated to be involved in the development, progression and metastasis in several human cancers. Constitutive activation of JAK/STAT3 signaling pathway has been reported to play an important role in the development and progression of hepatocellular carcinoma (HCC).The purpose of this study was to determine the biological roles and clinical significance of miR-500a-3p in HCC and to identify whether miR-500a-3p has an effect on the activity of JAK/STAT3 signaling in HCC.

Methods

miR-500a-3p expression was examined by real-time PCR in 8 paired HCC tissues and individual 120 HCC tissues respectively. Statistical analysis was performed to explore the clinical correlation between miR-500a-3p expression and clinicopathological features and overal

SUBMITTER: Jiang C 

PROVIDER: S-EPMC5532790 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature