Brand variation in oxidant production in mainstream cigarette smoke: Carbonyls and free radicals.

ABSTRACT: Oxidative stress/damage resulting from exposure to cigarette smoke plays a critical role in the development of tobacco-caused diseases. Carbonyls and free radicals are two major classes of oxidants in tobacco smoke. There is little information on the combined delivery of these oxidants across different cigarette brands; thus, we set out to measure and compare their levels in mainstream smoke from popular US cigarettes. Mainstream smoke from 28 different cigarette brands produced by smoking (FTC protocol) was analyzed for five important, abundant carbonyls, and levels were compared to previously determined free radical for the same brands. Overall, there were large variations (3- to 6-fold) in carbonyl levels across brands with total carbonyl levels ranging from 275 to 804 μg/cigarette, whi

SUBMITTER: Reilly SM 

PROVIDER: S-EPMC5532802 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature