Midkine concentrations in fine-needle aspiration of benign and malignant thyroid nodules.

ABSTRACT:

Context

The primary preoperative method for distinguishing malignant from benign thyroid nodules is fine-needle aspiration (FNA) cytology, but it is frequently inconclusive. Midkine (MDK) is a heparin-binding growth factor, which is overexpressed in papillary thyroid carcinoma (PTC).

Objective

We measured MDK concentrations in FNA samples from benign and malignant thyroid nodules to explore the possibility that MDK measurement might aid in the evaluation of thyroid nodules.

Design

35 subjects underwent preoperative FNA of 45 thyroid nodules, followed by thyroidectomy, providing a histological diagnosis. FNA needle contents were first expressed for cytology, and then, the needle was washed with buffer for immunoassay. In 46 subjects without preoperative FNA samples, FN

SUBMITTER: Jee YH 

PROVIDER: S-EPMC5532878 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature