In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood.

ABSTRACT:

Background

Particulate matter (PM; PM_2.5 [PM with diameters of <2.5 μm]) exposure during development is strongly associated with adverse cardiovascular outcomes at adulthood. In the present study, we tested the hypothesis that in utero PM_2.5 exposure alone could alter cardiac structure and function at adulthood.

Methods and results

Female FVB mice were exposed either to filtered air or PM_2.5 at an average concentration of 73.61 μg/m³ for 6 h/day, 7 days/week throughout pregnancy. After birth, animals were analyzed at 12 weeks of age. Echocardiographic (n=9-10 mice/group) and pressure-volume loop analyses (n=5 mice/group) revealed reduced fractional shortening, increased left ventricular end-systolic and -diastolic diameters, reduce

SUBMITTER: Tanwar V 

PROVIDER: S-EPMC5533043 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature