A genetic risk score that includes common type 2 diabetes risk variants is associated with gestational diabetes.

ABSTRACT:

Objective

Gestational diabetes (GDM) is characterized by maternal glucose intolerance that manifests during pregnancy. Because GDM resembles type 2 diabetes (T2DM), shared genetic predisposition is likely but has not been established. We tested the hypothesis that a genetic risk score (GRS) that included variants known to be associated with T2DM is associated with GDM.

Study design

We conducted a case-control study using the Vanderbilt Medical Center biobank (BioVU) and calculated a simple-count GRS using 34 variants previously associated with T2DM or fasting glucose in the general population, or with GDM or glucose intolerance in pregnancy. We assessed the association of the GRS with GDM adjusting for maternal age, parity, and body mass index (BMI) and calculated the area u

SUBMITTER: Kawai VK 

PROVIDER: S-EPMC5533106 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature