NF-kappa B activation correlates with disease phenotype in Crohn's disease.

ABSTRACT:

Background/aims

Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of Crohn's disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn's disease patients with varying levels of the NF-κB activation.

Methods

Crohn's disease patients who underwent surgical bowel resection were divided into two groups, based on the activation status of NF-κB. NF-κB activation was assessed by the immunoreactivity of nuclear NF-κB during immunohistochemical staining of bowel resection specimens. We compared the demographic, clinical and histologic characteristics between groups. Furthermore, the occurrence of reoperation, readmission, and medication change due to disease flare-up were investigated according to NF-

SUBMITTER: Han YM 

PROVIDER: S-EPMC5533307 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature