The bias of experimental design, including strain background, in the determination of critical Streptococcus suis serotype 2 virulence factors.

ABSTRACT: Streptococcus suis serotype 2 is an important porcine bacterial pathogen and emerging zoonotic agent mainly responsible for sudden death, septic shock, and meningitis. However, serotype 2 strains are genotypically and phenotypically heterogeneous. Though a multitude of virulence factors have been described for S. suis serotype 2, the lack of a clear definition regarding which ones are truly "critical" has created inconsistencies that have only recently been highlighted. Herein, the involvement of two factors previously described as being critical for S. suis serotype 2 virulence, whether the dipeptidyl peptidase IV and autolysin, were evaluated with regards to different ascribed functions using prototype strains belonging to important sequence types. Results demonstrate a lack of reproduci

SUBMITTER: Auger JP 

PROVIDER: S-EPMC5533308 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature