Simvastatin dose and acute kidney injury without concurrent serious muscle injury: A nationwide nested case-control study.

ABSTRACT:

Background

Inconsistent findings from four observational studies suggest that the risk of acute kidney injury (AKI) may increase with increasing statin dose or potency, but none of the studies took statin-related severe muscle injury, including rhabdomyolysis, into account. We undertook a nationwide nested case-control study in New Zealand to examine the risk of AKI without concurrent serious muscle injury according to simvastatin dose in two cohorts: people without a history of renal disease and people with non-dialysis dependent chronic kidney disease.

Materials and methods

A total of 334,710 people aged ≥ 18 years without a history of renal disease (cohort 1) and 5,437 with non-dialysis dependent chronic kidney disease (cohort 2) who initiated simvastatin therapy between

SUBMITTER: Parkin L 

PROVIDER: S-EPMC5533333 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature