Mechanical versus humoral determinants of brain death-induced lung injury.

ABSTRACT:

Background

The mechanisms of brain death (BD)-induced lung injury remain incompletely understood, as uncertainties persist about time-course and relative importance of mechanical and humoral perturbations.

Methods

Brain death was induced by slow intracranial blood infusion in anesthetized pigs after randomization to placebo (n = 11) or to methylprednisolone (n = 8) to inhibit the expression of pro-inflammatory mediators. Pulmonary artery pressure (PAP), wedged PAP (PAWP), pulmonary vascular resistance (PVR) and effective pulmonary capillary pressure (PCP) were measured 1 and 5 hours after Cushing reflex. Lung tissue was sampled to determine gene expressions of cytokines and oxidative stress molecules, and pathologically score lung injury.

Results

Intracranial hyperten

SUBMITTER: Belhaj A 

PROVIDER: S-EPMC5533440 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature