Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty.

ABSTRACT: We make choices based on the values of expected outcomes, informed by previous experience in similar settings. When the outcomes of our decisions consistently violate expectations, new learning is needed to maximize rewards. Yet not every surprising event indicates a meaningful change in the environment. Even when conditions are stable overall, outcomes of a single experience can still be unpredictable due to small fluctuations (i.e., expected uncertainty) in reward or costs. In the present work, we investigate causal contributions of the basolateral amygdala (BLA) and orbitofrontal cortex (OFC) in rats to learning under expected outcome uncertainty in a novel delay-based task that incorporates both predictable fluctuations and directional shifts in outcome values. We demonstrate that OFC

SUBMITTER: Stolyarova A 

PROVIDER: S-EPMC5533586 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature