High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes.

ABSTRACT:

Background & aims

Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area.

Methods

We collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diabetes Autoimmunity Study in the Young. Subjects with susceptibility genotypes for celiac disease and type 1 diabetes were followed up for up to 20 years for development of tissue transglutaminase autoantibodies (tTGA). Outcomes were the development of celiac disease autoimmunity (CDA) or celiac disease. CDA was defined as persistence of tTGA for at least 3 months or development of celiac

SUBMITTER: Liu E 

PROVIDER: S-EPMC5533620 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature