Phthalates and thyroid function in preschool age children: Sex specific associations.

ABSTRACT:

Background

Research relating either prenatal or concurrent measures of phthalate exposure to thyroid function in preschool children is inconclusive.

Methods

In a study of inner-city mothers and their children, metabolites of di-n-butyl phthalate, butylbenzyl phthalate, di-isobutyl phthalate, di(2-ethylhexyl) phthalate, and diethyl phthalate were measured in a spot urine sample collected from women in late pregnancy and from their children at age 3years. We measured children's serum free thyroxine (FT4) and thyroid stimulating hormone (TSH) at age 3. Linear regression models were used to investigate the associations between phthalate metabolites, measured in maternal urine during late pregnancy and measured in child urine at age 3 and thyroid function measured at age 3.

Re

SUBMITTER: Morgenstern R 

PROVIDER: S-EPMC5533628 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature