Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family.

ABSTRACT: The emergence of genes implicated across multiple comorbid neurologic disorders allows to identify shared underlying molecular pathways. Recently, investigation of patients with diverse neurologic disorders found TANC1 and TANC2 as possible candidate disease genes. While the TANC proteins have been reported as postsynaptic scaffolds influencing synaptic spines and excitatory synapse strength, their molecular functions remain unknown. Here, we conducted a comprehensive in silico analysis of the TANC protein family to characterize their molecular role and understand possible neurobiological consequences of their disruption. The known Ankyrin and tetratricopeptide repeat (TPR) domains have been modeled. The newly predicted N-terminal ATPase domain may function as a regulated molecular switch

SUBMITTER: Gasparini A 

PROVIDER: S-EPMC5533708 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature