Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism - A Cohort Study.

ABSTRACT: Prior cross-sectional analyses have demonstrated an association between subclinical hypothyroidism and metabolic syndrome and selected components. However, the temporal relation between metabolic syndrome and declining thyroid function remains unclear. In a prospective study, an unselected cohort of 66,822 participants with and without metabolic syndrome were followed. A proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% CIs for hypothyroidism. Exploratory analyses for the relation between components of metabolic syndrome and declining thyroid function were also undertaken. During an average follow-up of 4.2 years, the incident rates for subclinical hypothyroidism were substantially higher in participants who began the study with metabolic syndrome compa

SUBMITTER: Chang CH 

PROVIDER: S-EPMC5533753 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature