Investigation of simultaneously existed Raman scattering enhancement and inhibiting fluorescence using surface modified gold nanostars as SERS probes.

ABSTRACT: One of the main challenges for highly sensitive surface-enhanced Raman scattering (SERS) detection is the noise interference of fluorescence signals arising from the analyte molecules. Here we used three types of gold nanostars (GNSs) SERS probes treated by different surface modification methods to reveal the simultaneously existed Raman scattering enhancement and inhibiting fluorescence behaviors during the SERS detection process. As the distance between the metal nanostructures and the analyte molecules can be well controlled by these three surface modification methods, we demonstrated that the fluorescence signals can be either quenched or enhanced during the detection. We found that fluorescence quenching will occur when analyte molecules are closely contacted to the surface of GNSs, l

SUBMITTER: Shan F 

PROVIDER: S-EPMC5533772 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature