Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations.

ABSTRACT: Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain is assessed using direct membrane feeding assays and murine antibodies in Burkina Faso. The transmission blocking activity of both candidates depends on the level of parasite exposure (as assessed by the mean number of oocysts in control mosquitoes) and antibody titers. A mathematical framework is devised to allow the efficacy of different candidates to be directly compared and determine the minimal antibody titers re

SUBMITTER: Bompard A 

PROVIDER: S-EPMC5533793 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature