Interactions between glycopyrronium and indacaterol on cholinergic neurotransmission and contractile response in bovine trachealis.

ABSTRACT:

Background

Muscarinic-receptor antagonists and β-adrenoceptor agonists are used, alone or in combination, as first-line treatment for chronic obstructive pulmonary disease. Both drugs decrease airway smooth muscle tone by post-junctional mechanisms but they may have opposing effects on pre-junctional acetylcholine (ACh)-release.

Methods

We studied the effects of the muscarinic-receptor antagonist glycopyrronium (GLY), the β-adrenoceptor agonist indacaterol (IND) and their combination on electrically-induced ACh-release and contractile response in isolated bovine trachealis. Data were analyzed by paired t-test and analysis of variance for repeated or independent measures with Newmann-Keuls post-hoc test when appropriate.

Results

GLY 10^-8 M decreased contract

SUBMITTER: Baroffio M 

PROVIDER: S-EPMC5534043 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature