Manatee invariants reveal functional pathways in signaling networks.

ABSTRACT:

Background

Signal transduction pathways are important cellular processes to maintain the cell's integrity. Their imbalance can cause severe pathologies. As signal transduction pathways feature complex regulations, they form intertwined networks. Mathematical models aim to capture their regulatory logic and allow an unbiased analysis of robustness and vulnerability of the signaling network. Pathway detection is yet a challenge for the analysis of signaling networks in the field of systems biology. A rigorous mathematical formalism is lacking to identify all possible signal flows in a network model.

Results

In this paper, we introduce the concept of Manatee invariants for the analysis of signal transduction networks. We present an algorithm for the characterization of the comb

SUBMITTER: Amstein L 

PROVIDER: S-EPMC5534052 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature