Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis.

ABSTRACT:

Background

In multiple sclerosis, coagulation factors have been shown to modulate inflammation. In this translational study, we investigated whether long-term anticoagulation with warfarin or rivaroxaban has beneficial effects on the course of autoimmune experimental encephalomyelitis (EAE).

Methods

Female SJL/J mice treated with anticoagulants namely warfarin or rivaroxaban were immunized with PLP_139-151. Stable anticoagulation was maintained throughout the entire experiment. Mice without anticoagulation treated with the vehicle only were used as controls. The neurological deficit was recorded during the course of EAE, and histopathological analyses of inflammatory lesions were performed.

Results

In preventive settings, both treatment with warfarin and riv

SUBMITTER: Stolz L 

PROVIDER: S-EPMC5534067 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature