Coiled-coil domain containing 109B is a HIF1α-regulated gene critical for progression of human gliomas.

ABSTRACT:

Background

The coiled-coil domain is a structural motif found in proteins that participate in a variety of biological processes. Aberrant expression of such proteins has been shown to be associated with the malignant behavior of human cancers. In this study, we investigated the role of a specific family member, coiled-coil domain containing 109B (CCDC109B), in human gliomas.

Methods and results

We confirmed that CCDC109B was highly expressed in high grade gliomas (HGG; WHO III-IV) using immunofluorescence, western blot analysis, immunohistochemistry (IHC) and open databases. Through Cox regression analysis of The Cancer Genome Atlas (TCGA) database, we found that the expression levels of CCDC109B were inversely correlated with patient overall survival and it could serve as a

SUBMITTER: Xu R 

PROVIDER: S-EPMC5534085 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature