Systemic cytokine and chemokine responses in immunized mice challenged with staphylococcal enterotoxin B.

ABSTRACT: The cytokine storm induced by staphylococcal enterotoxin B (SEB) describes the rapid and dramatic induction of mediators which are likely responsible for the toxin's deleterious effects. However despite the use of numerous animal models for investigating SEB related illness in humans, mechanisms of toxicity and correlates of protection remain unclear. In the present study, we used an LPS-potentiated model of SEB lethality to investigate the toxin-induced cytokine and chemokine responses in untreated and immunized mice. Of 30 separate mediators analyzed, serum levels for 28 or 27 of these cytokines and chemokines were elevated following administration of dosages of 3 or 30 LD₅₀ of native SEB, respectively. Mice immunized with a non-toxic SEB vaccine candidate expressed in either

SUBMITTER: Hudson Reichenberg LC 

PROVIDER: S-EPMC5534135 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature