Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress.

ABSTRACT:

Background

The nucleus accumbens is a critical mediator of depression-related outcomes to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in the two medium spiny neuron (MSN) subtypes, those enriched in dopamine receptor D1 versus dopamine receptor D2, in reward and reinforcement leading to opposing roles for these MSNs in these behaviors. However, the distinct roles of nucleus accumbens MSN subtypes, in depression, remain poorly understood.

Methods

Using whole-cell patch clamp electrophysiology, we examined excitatory input to MSN subtypes and intrinsic excitability measures in D1-green fluorescent protein and D2-green fluorescent protein bacterial artificial chromosome transgenic mice that underwent chronic social defeat stress (CSDS

SUBMITTER: Francis TC 

PROVIDER: S-EPMC5534173 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature