Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI.

ABSTRACT:

Background

Understanding brain function requires knowledge of how one brain region causally influences another. This information is difficult to obtain directly in the human brain, and is instead typically inferred from resting-state fMRI.

New method

Here, we demonstrate the safety and scientific promise of a novel and complementary approach: concurrent electrical stimulation and fMRI (es-fMRI) at 3T in awake neurosurgical patients with implanted depth electrodes.

Results

We document the results of safety testing, actual experimental setup, and stimulation parameters, that safely and reliably evoke activation in distal structures through stimulation of amygdala, cingulate, or prefrontal cortex. We compare connectivity inferred from the evoked patterns of activation wi

SUBMITTER: Oya H 

PROVIDER: S-EPMC5534177 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature