Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hurthle Cell Neoplasms: A Retrospective Analysis.

ABSTRACT:

Purpose

Although currently classified as variants of follicular neoplasms (FNs), Hürthle cell neoplasms (HCNs) exhibit distinct biological characteristics. Hence, the metabolism of both neoplasms may also be different. The aims of this study were to investigate and compare the expression of glycolysis-related proteins in HCNs and FNs and to determine the clinical implications of such expression.

Methods

Tissue microarrays were constructed with 265 samples of FNs (112 follicular carcinomas (FCs) and 153 follicular adenomas (FAs)) as well as 108 samples of HCNs (27 Hürthle cell carcinomas (HCCs) and 81 Hürthle cell adenomas (HCAs)). Immunohistochemical staining for the glycolysis-related molecules Glut-1, hexokinase II, CAIX, and MCT4 was performed.

Results

The expressi

SUBMITTER: Kim HM 

PROVIDER: S-EPMC5534281 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature