Similar Ratios of Introns to Intergenic Sequence across Animal Genomes.

ABSTRACT: One central goal of genome biology is to understand how the usage of the genome differs between organisms. Our knowledge of genome composition, needed for downstream inferences, is critically dependent on gene annotations, yet problems associated with gene annotation and assembly errors are usually ignored in comparative genomics. Here, we analyze the genomes of 68 species across 12 animal phyla and some single-cell eukaryotes for general trends in genome composition and transcription, taking into account problems of gene annotation. We show that, regardless of genome size, the ratio of introns to intergenic sequence is comparable across essentially all animals, with nearly all deviations dominated by increased intergenic sequence. Genomes of model organisms have ratios much closer to 1:1,

SUBMITTER: Francis WR 

PROVIDER: S-EPMC5534336 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature