Engineering the Bacterial Microcompartment Domain for Molecular Scaffolding Applications.

ABSTRACT: As synthetic biology advances the intricacy of engineered biological systems, the importance of spatial organization within the cellular environment must not be marginalized. Increasingly, biological engineers are investigating means to control spatial organization within the cell, mimicking strategies used by natural pathways to increase flux and reduce cross-talk. A modular platform for constructing a diverse set of defined, programmable architectures would greatly assist in improving yields from introduced metabolic pathways and increasing insulation of other heterologous systems. Here, we review recent research on the shell proteins of bacterial microcompartments and discuss their potential application as "building blocks" for a range of customized intracellular scaffolds. We summarize

SUBMITTER: Young EJ 

PROVIDER: S-EPMC5534457 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature