Trypanosoma Infection Favors Brucella Elimination via IL-12/IFNγ-Dependent Pathways.

ABSTRACT: This study develops an original co-infection model in mice using Brucella melitensis, the most frequent cause of human brucellosis, and Trypanosoma brucei, the agent of African trypanosomiasis. Although the immunosuppressive effects of T. brucei in natural hosts and mice models are well established, we observed that the injection of T. brucei in mice chronically infected with B. melitensis induces a drastic reduction in the number of B. melitensis in the spleen, the main reservoir of the infection. Similar results are obtained with Brucella abortus- and Brucella suis-infected mice and B. melitensis-infected mice co-infected with Trypanosoma cruzi, demonstrating that this phenomenon is not due to antigenic cross-reactivit

SUBMITTER: Machelart A 

PROVIDER: S-EPMC5534484 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature