The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis.

ABSTRACT:

Objective

To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC.

Design

A systematic review was conducted using MEDLINE, Embase, PubMed and Current Contents Connect to identify studies published between January 1990 and February 2015 of oesophageal cancer populations (with OAC diagnoses >50% of cases) that measured tumoural TP53 status and reported hazard ratios (HR), or adequate data for estimation of HR for survival for TP53-defined subgroups. Risk of bias for HR estimates was assessed using prespecified criteria for the appraisal of relevant domains as defined by the Cochrane Prognosis Methods Group including adherence

SUBMITTER: Fisher OM 

PROVIDER: S-EPMC5534764 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature