Gene-body 5-hydroxymethylation is associated with gene expression changes in the prefrontal cortex of depressed individuals.

ABSTRACT: 5-Hydroxymethylcytosine (5hmC) is a recently characterized epigenetic mark that is particularly abundant in brain tissue and that regulates gene transcription. We have recently begun to understand the important role of 5hmC in brain development, plasticity and disease, but there are currently little data on 5hmC alterations in psychiatric illnesses. Here we report what we believe to be the first genome-wide analysis of 5hmC in the depressed brain. Using AbaSI sequencing, we investigated 5hmC in the prefrontal cortex of depressed (N=19) and psychiatrically healthy controls (N=19). Consistent with previous global 5hmC analyses in other phenotypes, and likely owing to the inter-individual variability in 5hmC content, the distribution of 5hmC across chromosomes and genomic features was not dif

SUBMITTER: Gross JA 

PROVIDER: S-EPMC5534961 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature