Loss of the clock protein PER2 shortens the erythrocyte life span in mice.

ABSTRACT: Cell proliferation and release from the bone marrow have been demonstrated to be controlled by circadian rhythms in both humans and mice. However, it is unclear whether local circadian clocks in the bone marrow influence physiological functions and life span of erythrocytes. Here, we report that loss of the clock gene Per2 significantly decreased erythrocyte life span. Mice deficient in Per2 were more susceptible to acute stresses in the erythrocytes, becoming severely anemic upon phenylhydrazine, osmotic, and H₂O₂ challenges. ¹H NMR-based metabolomics analysis revealed that the Per2 depletion causes significant changes in metabolic profiles of erythrocytes, including increased lactate and decreased ATP levels compared with wild-type mi

SUBMITTER: Sun Q 

PROVIDER: S-EPMC5535041 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature