Explicit consideration of baseline factors to assess recombinant tissue-type plasminogen activator response with respect to race and sex.

ABSTRACT:

Background and purpose

Sex and race reportedly influence outcome after recombinant tissue-type plasminogen activator (rtPA). It is, however, unclear whether baseline imbalances (eg, stroke severity) or lack of response to thrombolysis is responsible. We applied balancing methods to test the hypothesis that race and sex influence outcome after rtPA independent of baseline conditions.

Methods

We mapped group outcomes from the National Institute of Neurological Disorders and Stroke (NINDS) dataset based on race and sex onto a surrogate-control function to assess differences from expected outcomes at their respective National Institutes of Health Stroke Scale and age. Outcomes were also compared for subjects matched individually on key baseline factors using NINDS and 2 recent d

SUBMITTER: Mandava P 

PROVIDER: S-EPMC5535075 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature