Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC.

ABSTRACT: Chronic exposure to arsenic, most often through contaminated drinking water, has been linked to several types of cancer in humans, including skin and lung cancer. However, the mechanisms underlying its role in causing cancer are not well understood. There is evidence that exposure to arsenic can enhance the carcinogenicity of UV light in inducing skin cancers and may enhance the carcinogenicity of tobacco smoke in inducing lung cancers. The nucleotide excision repair (NER) pathway removes different types of DNA damage including those produced by UV light and components of tobacco smoke. The aim of the present study was to investigate the effect of sodium arsenite on the NER pathway in human lung fibroblasts (IMR-90 cells) and primary mouse keratinocytes. To measure NER, we employed a slot-

SUBMITTER: Holcomb N 

PROVIDER: S-EPMC5535078 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature