Heart failure hospitalization risk associated with use of two classes of oral antidiabetic medications: an observational, real-world analysis.

ABSTRACT:

Background

Newer oral antidiabetic drug classes are expanding treatment options for type 2 diabetes mellitus (T2DM); however, concerns remain. The objective was to assess relative risk of heart failure hospitalization of sodium-glucose co-transporter-2 (SGLT2) and dipeptidyl peptidase-4 (DPP4) inhibitors in T2DM patients.

Methods

This retrospective observational study used a national commercially insured claims database. Adults (>18 years) with T2DM newly starting SGLT2 or DPP4 medication between April 2013 and December 2014 were included. Depending on their index fill, patients were grouped into either SGLT2 or DPP4 medication class cohorts. The primary outcome was hospitalization for heart failure and the risk was assessed using Cox regression models. Propensity score matc

SUBMITTER: Gautam S 

PROVIDER: S-EPMC5535291 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature