Assessment of Virus Interference in a Test-negative Study of Influenza Vaccine Effectiveness.

ABSTRACT:

Background

The observational test-negative study design is used to estimate vaccine effectiveness against influenza virus infection. An important assumption of the test-negative design is that vaccination does not affect the risk of infection with another virus. If such virus interference occurred, detection of other respiratory viruses would be more common among influenza vaccine recipients and vaccine effectiveness estimates could differ. We evaluated the potential for virus interference using data from the Influenza Incidence Surveillance Project.

Methods

From 2010 to 2013, outpatients presenting to clinics in 13 US jurisdictions with acute respiratory infections were tested for influenza and other respiratory viruses. We investigated whether virus interference might affe

SUBMITTER: Feng S 

PROVIDER: S-EPMC5535302 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature